Developing an isotope separation means knowing where the activity is at every step, not just what ends up in the final fraction. Radiochemistry and nuclear physics laboratories need to watch a separation as it runs, quantify each fraction at the bench, and optimize the process before it ever reaches production. PHDS HPGe systems bring spatial imaging and high-resolution spectroscopy to the development bench and the hot cell, with no liquid nitrogen and no fixed counting room.
Real-time imaging of separation dynamics
The NP Imager images radioisotope distributions in space, in real time, without interrupting the measurement. Instead of inferring how a separation behaved from a series of fraction assays, you can watch activity move through a column, monitor hot cell contents, and follow a harvesting process as it happens. Compton and pinhole imaging with a 1× to 6× ZoomFactor resolves where each isotope sits and how it migrates, so you can characterize and optimize a separation by direct observation.
Bench-scale quantification
The Fulcrum-L laboratory HPGe spectrometer quantifies the isotopes in each fraction with the resolution to separate closely spaced lines. It resolves gamma lines to better than 1.0 keV FWHM at 122 keV and covers 40 keV to 3 MeV, enough to pull a product line cleanly away from a neighboring daughter or impurity. That matters for short-lived medical isotopes like Ac-225 and its decay chain. A long-life Stirling cooler means no liquid nitrogen at the bench, and the compact footprint fits beside the work.
Harvesting and process development
The same instruments support radioisotope harvesting at accelerator and reactor facilities and the process-development work that precedes production: characterizing harvested activity, tracking radionuclidic composition as a separation is refined, and confirming that a process hits its purity targets before it scales up.
When the process moves to production
Once a separation is developed and the workflow is ready for GMP production and batch release, the same Fulcrum-L pairs with WinOMNI-GMP and the Shield Cart to form a compliant QC station.
